2-Chloropyrimidine

Base Information

  • PRODUCT:2-Chloropyrimidine
  • CAS.:1722-12-9
  • MF:C4H3ClN2
  • Molecular Weight:114.534
  • Purity:99%

Product Details

CAS： 1722-12-9

MF： C4H3ClN2

Appearance： yellowish to pale orange crystals or cryst. powder

Factory Supply High Purity Best Quality 2-Chloropyrimidine 1722-12-9 Efficient Shipping

  • Molecular Formula:C4H3ClN2
  • Molecular Weight:114.534
  • Appearance/Colour:yellowish to pale orange crystals or cryst. powder 
  • Vapor Pressure:0.487mmHg at 25°C 
  • Melting Point:63-66 °C(lit.) 
  • Refractive Index:1.534 
  • Boiling Point:199.2 °C at 760 mmHg 
  • PKA:-1.46±0.13(Predicted) 
  • Flash Point:109.2 °C 
  • PSA：25.78000 
  • Density:1.303 g/cm3 
  • LogP:1.13000 

2-Chloropyrimidine(Cas 1722-12-9) Usage

Chemical Properties

yellowish to pale orange crystals or cryst. powder

Uses

 2-Chloropyrimidine is a monochlorinated pyrimidine compound known for its plant growth-regulating properties. It serves as a valuable reagent in the synthesis of antiviral drugs and other biologically active compounds. This chemical is particularly useful in cobalt-catalyzed cross-coupling reactions with aryl halides. It can be purified through recrystallization from solvents like benzene (C6H6), petroleum ether, or a mixture of both. 2-Chloropyrimidine exhibits sublimation at 50°C/18mmHg and can be distilled under vacuum conditions. These characteristics make it a versatile compound for various chemical reactions and processes, especially in the development of pharmaceuticals and biologically active substances.

Consumer Uses

ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

InChI:InChI=1/C4H3ClN2/c5-4-6-2-1-3-7-4/h1-3H

1722-12-9 Relevant articles

Electrochemical cross-coupling between functionalized aryl halides and 2-chloropyrimidine or 2-chloropyrazine catalyzed by nickel 2,2′-bipyridine complex

Corinne Gosmini, Jean Yves Nédélec, Jacques Périchon

, Tetrahedron Letters Volume 41, Issue 2, 8 January 2000, Pages 201-203

2-Arylpyrimidines and 2-arylpyrazines have been obtained in good to high yields from 2-chloropyrimidine and 2-chloropyrazine and various functionalized aryl halides by electroreduction using an iron rod as the anode and a catalytic amount of nickel–bipyridine complex in a mixture of DMF and pyridine as solvent.

Two-color two-photon REMPI and ZEKE photoelectron spectroscopy of jet-cooled 2-chloropyrimidine

Y He, C Wu, W Kong

, Chemical physics letters, 2004

We report studies of supersonically cooled 2-chloropyrimidine (2-ClP) using two-color resonantly enhanced multiphoton ionization (REMPI) and two-color zero kinetic energy (ZEKE) …

Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties

Wang, Bao-Lei,Shi, Yan-Xia,Zhang, Shu-Jun,Ma, Yi,Wang, Hong-Xue,Zhang, Li-Yuan,Wei, Wei,Liu, Xing-Hai,Li, Yong-Hong,Li, Zheng-Ming,Li, Bao-Ju

, p. 167 - 178 (2016/04/26)

A series of novel carboxamide compounds ...

1722-12-9 Process route

1-benzylpyrazole
10199-67-4

1-benzylpyrazole

chloroform
67-66-3,8013-54-5

chloroform

2-chloropyrimidine
1722-12-9,1195939-87-7

2-chloropyrimidine

2-phenylpyrimidine
7431-45-0

2-phenylpyrimidine

α-carboline
244-76-8

α-carboline

Conditions
Conditions Yield
at 550 - 555 ℃; Title compound not separated from byproducts;
 
1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine
202344-41-0

1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine

NH-pyrazole
288-13-1

NH-pyrazole

2-chloropyrimidine
1722-12-9,1195939-87-7

2-chloropyrimidine

9H-pyrrolo[2,3-b:5,4-c']dipyridine
7266-32-2

9H-pyrrolo[2,3-b:5,4-c']dipyridine

Conditions
Conditions Yield
With chloroform; at 550 - 555 ℃; Title compound not separated from byproducts;
 
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