What is the Carbamazepine?

Carbamazepine is white solid, while it's Molecular Formula is C15H12N2O. white solid Carbamazepine (CBZ) is a first generation anticonvulsant and mood stabilizing compound that has been used as a therapeutic in the context of neuropathic pain, epilepsy, and affective disorders. It exerts its effects by blocking voltage-gated sodium channels (IC50 = 640 μM), making fewer of these channels available to subsequently open, which leads to decreased high-frequency repetitive firing of action potentials. The estimated IC50 values for inhibition of Nav1.7-, Nav1.3-, and Nav1.8-type channels by CBZ following prolonged inactivation have been reported as 406, 900, and 138 μM, respectively. CBZ can also inhibit L-type Ca2+ channels (IC50 = 974 μM) and has been shown to potentiate GABAA receptors (IC50 >3 mM).

What is the CAS number for Carbamazepine?

The CAS number of Carbamazepine is 298-46-4.

What is Carbamazepine (298-46-4) used for?

Carbamazepine is a synthetic iminostilbene derivative structurallysimilar to imipramine, a tricyclic antidepressant. Whileunrelated structurally, carbamazepine shares a similar therapeuticaction with phenytoin. Carbamazepine was first discoveredin 1953 by Swiss chemist Walter Schindler. Throughout the1960s, antimuscarinic was used and marketed for trigeminalneuralgia and as an anticonvulsant. By the 1970s, it was beingused as a mood stabilizer for patients with bipolar disorder.InChI:InChI=1/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

Carbamazepine

Base Information

PRODUCT:Carbamazepine
CAS.:298-46-4
MF:C₁₅H₁₂N₂O
Molecular Weight:236.273
Purity:99%

Product Details

CAS： 298-46-4

MF： C₁₅H₁₂N₂O

Appearance： white solid

Quality Manufacturer Supply Best Quality Carbamazepine 298-46-4 with Efficient Shipping

Molecular Formula:C15H12N2O
Molecular Weight:236.273
Appearance/Colour:white solid
Vapor Pressure:5.78E-07mmHg at 25°C
Melting Point:189-192 °C
Refractive Index:1.669
Boiling Point:410.984 °C at 760 mmHg
PKA:13.94±0.20(Predicted)
Flash Point:202.356 °C
PSA：46.33000
Density:1.266 g/cm³
LogP:4.15250

Carbamazepine(Cas 298-46-4) Usage

Overview	Carbamazepine (CBZ) is a medication primarily used to treat epilepsy and trigeminal neuralgia. It belongs to the class of drugs known as antiepileptic drugs (AEDs). While initially developed for epilepsy, it has also found applications in the treatment of psychiatric disorders, particularly manic depressive psychosis. Studies have demonstrated the efficacy of CBZ in managing acute manic and depressive symptoms in bipolar disorder, as well as in prophylaxis. However, long-term prophylactic efficacy can vary, with some concerns about tolerance development. CBZ has also shown potential for treating unipolar depression, aggressive agitation in demented patients, super-sensitivity psychosis, and alcohol and benzodiazepine withdrawal syndromes. It has been explored in panic disorders, but the results are mixed.
Cautions	Patients with a history of hepatic porphyrias. Patients with a history of bone marrow depression. Patients with atrioventricular block. Patients with a history of haematological reactions to other drugs. Patients with susceptibility to angle- closure glaucoma. Patients with skin reactions. Patients with cardiac disease. Patients with absence and myoclonic seizures.
Originator	Tegretol,Geigy,W. Germany,1964
Uses	Carbamazepine (CBZ) is a versatile medication used for various medical conditions: Epilepsy: CBZ is effective in treating both partial seizures and generalized tonic–clonic seizures. However, it is contraindicated in absence epilepsy. Trigeminal Neuralgia: CBZ is a valuable treatment for trigeminal neuralgia, a condition characterized by severe facial pain. Bipolar Disorders: CBZ is utilized for managing bipolar disorders, particularly in the treatment of acute manic states and prophylaxis. While it may be less effective than some other medications like valproate or lithium, it can be a better choice for certain atypical manifestations of bipolar disorder, such as rapid cycling course or mood-incongruent delusions, and in the presence of co-morbid psychiatric or neurological conditions. Unipolar Depression: There is evidence to suggest that CBZ may be effective in treating unipolar depression. Other Uses: CBZ has been explored in the treatment of various psychiatric and neurological conditions, such as aggressive behavior in demented patients, super-sensitivity psychosis, and alcohol or benzodiazepine withdrawal syndromes. It may also have applications in panic disorders, although the results are mixed. CBZ should be administered at appropriate dosages tailored to each condition, and it is generally well-tolerated with few psychiatric side effects reported. However, cognitive issues, particularly at high doses, may occur occasionally. It's important to consider drug interactions, as CBZ can affect the plasma concentrations of various other drugs, both increasing and decreasing their levels.
Brand name	Carbatrol (Shire); Epitol (Teva); Equetro (Shire); Tegretol (Novartis); Teril (Taro).
Therapeutic Function	Analgesic, Anticonvulsant
Biochem/physiol Actions	Anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Sodium channel inhibitor.
Toxicity evaluation	Environmental exposure occurs via direct release into water or via vaporization into the air. It is susceptible to photolysis and is thought to have a half-life of roughly 63 days in lake water in vitro. However, when dissolved and exposed to direct photolysis, it has a half-life of approximately 1 day.

InChI:InChI=1/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

298-46-4 Relevant articles

Preparation, characterization and in vivo conversion of new water-soluble sulfenamide prodrugs of carbamazepine

Hemenway, Jeffrey N.,Nti-Addae, Kwame,Guarino, Victor R.,Stella, Valentino J.

, p. 6629 - 6632 (2007)

Improved synthetic methods are reported ...

Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltration

M. Clara, B. Strenn, N. Kreuzinger

, Water Research Volume 38, Issue 4, February 2004, Pages 947-954

Carbamazepine, an antiepileptic drug, is commonly found in sewage treatment plant (STP) effluents, contributing to pharmaceutical residues in surface waters. High concentrations of Carbamazepine have been detected in surface waters, raising environmental concerns. The solids retention time (SRT) is a crucial factor in STP design, affecting microorganism growth and effluent quality. Lab-scale studies investigated how SRT influences Carbamazepine removal, with results validated on full-scale STPs.

Site-Selective Acceptorless Dehydrogenation of Aliphatics Enabled by Organophotoredox/Cobalt Dual Catalysis

Zhou, Min-Jie,Zhang, Lei,Liu, Guixia,Xu, Chen,Huang, Zheng

supporting information, p. 16470 - 16485 (2021/10/20)

The value of catalytic dehydrogenation o...

298-46-4 Process route

: N-(2,2,2-trichloroacetyl)-5H-dibenz[b,f]azepine

: 298-46-4
carbamazepin

: 256-96-2
dibenzoazepine

Conditions

Conditions	Yield
With sodium carbonate; In water; Reagent/catalyst;

: C₂₅H₁₈N₄O₇

: 298-46-4
carbamazepin

: 256-96-2
dibenzoazepine